The event attracts the world's biggest music stars and is now in its 30th year. Past award ceremonies have seen live performances by the likes of Muse, Stormzy, Lewis Capaldi, Ed Sheeran and Dua Lipa, Evening Standard reports
This is the first time the show, billed as "music's biggest global celebration" will be staged in the city and marks an epic return of the EMAs to the UK after seven years.
The event will be broadcast from Manchester’s brand-new, purpose-built live entertainment arena Co-op Live on MTV in over 150 countries on Sunday, November 10. It is set to "honour and unite music’s brightest stars".
The decision to hold the event in Manchester has been hailed as a "superb platform" by Manchester Council bosses.
Council leader Bev Craig said: "As a city that is known the world over for our legendary music scene, MTV could not have picked a better place for this year's EMAs.
"With the expertise, experience and reputation we also have for delivering successful, world-class events, we're confident Manchester will provide a superb platform for the best MTV EMAs yet, and look forward to welcoming MTV and the global music community to our city for what is set to be an epic celebration of music and artists. Manchester meets MTV - we can't wait!"
It is set to be announced soon how the public will be able to get tickets to attend the live event. The show will additionally be available to view in multiple territories across the world on Pluto TV and on-demand on Paramount+.
Bruce Gillmer, President of Music, Music Talent, Programming & Events, Paramount, and Chief Content Officer, Music, Paramount+ said: "The MTV EMAs is one of the biggest global music celebrations, bringing together local and international artists to create iconic performances for fans around the world.